IGF-1 Long R3 100mcg

IGF-1 LR3 (Long R3 Insulin-Like Growth Factor 1) is a synthetic, lengthened analogue of human IGF-1, designed to exhibit greater metabolic stability and reduced binding to IGF-binding proteins (IGFBPs). It differs from native IGF-1 by having an arginine substitution at the third amino acid (“R3”) and an additional 13 amino acids at the N-terminus, making it significantly more potent in receptor activation studies.

This research-grade peptide is frequently utilised in experimental settings investigating cellular proliferation, survival pathways, and tissue regeneration mechanisms. IGF-1 LR3 is provided as a lyophilised powder for laboratory research use only.

Research Focus and Areas of Interest

1. Enhanced IGF-1 Receptor Binding and Activation

The arginine substitution and extended N-terminus confer reduced affinity for IGFBPs, allowing greater bioavailability and receptor interaction. This modification enables IGF-1 LR3 to serve as a superior model for examining IGF-1 receptor (IGF-1R) signalling and downstream activation of PI3K/Akt and MAPK pathways in controlled studies.

2. Cellular Proliferation and Differentiation Studies

IGF-1 LR3 is widely used in vitro to explore cell growth, survival, and differentiation, particularly in skeletal muscle, fibroblast, and neuronal models. Its enhanced receptor activity provides valuable insights into cell cycle regulation and anabolic signalling.

3. Research in Muscle Regeneration and Repair

Due to its capacity to promote myoblast fusion and myotube maturation, IGF-1 LR3 is utilised in myogenic and regenerative biology research. Its stability and potency allow scientists to simulate muscle recovery and tissue regeneration dynamics more effectively than native IGF-1.

4. Neuroprotection and Cellular Longevity

IGF-1 LR3 has also been studied for its neurotrophic and cytoprotective properties, making it of interest in neurobiology research models exploring neuronal survival, synaptic function, and oxidative stress resilience.

5. Collagen Production and Fibroblast Activity

The peptide’s role in fibroblast activation and collagen synthesis renders it relevant for studies into wound-healing and extracellular matrix remodelling, aiding research into dermal and connective tissue restoration mechanisms.

Conclusion

IGF-1 LR3 (Long R3 Insulin-Like Growth Factor 1) is a powerful research analogue engineered for superior receptor engagement and stability compared to native IGF-1. It is a key compound in growth factor, cellular repair, and regenerative biology studies. This peptide is strictly intended for laboratory research and not for human or veterinary use.

Technical Information

Synonyms: IGF-1 Long R3; IGF-1 LR3; LR3-IGF-1; Long Arginine 3 IGF-1
Sequence: MFPAMPLSSL FVNGPRTLCG AELVDALQFV CGDRGFYFNK PTGYGSSSRR APQTGIVDEC CFRSCDLRRL EMYCAPLKPA KSA
Molecular Weight: 9,117.6 g/mol
CAS Number: 143045-27-6
Further Reference: Wikipedia – IGF-1 LR3
Source: Biosynthesis
Reconstitution: Reconstitute with Acetic Acid or a mixture of Acetic Acid + Bacteriostatic Water
PubChem Link

Stability, Storage, and Handling

Stability: Store lyophilised peptide at –20 °C. After reconstitution, aliquot to avoid repeated freeze–thaw cycles. Reconstituted material may be stored at 4 °C for short-term use. The lyophilised compound remains stable until its expiry date when stored properly.
Usage: Product is supplied for LABORATORY RESEARCH ONLY. IGF-1 LR3 for sale at Pure Peptides UK is intended exclusively for scientific research and educational applications. Purchase permitted only to licensed researchers.