Adipotide (FTPP) 5mg

Adipotide (FTPP) – 5mg

Adipotide (FTPP), also known as prohibitin-targeting peptide 1, is a synthetic peptidomimetic supplied as a lyophilised powder for research use only. It is designed with a bifunctional structure: a targeting sequence that binds to prohibitin/ANXA2 proteins on blood vessels, and a pro-apoptotic domain (_D(KLAKLAK)_2) that disrupts mitochondrial function. This selective action makes Adipotide a research tool of interest in studies of adipose tissue biology, metabolic regulation, and vascular targeting strategies.

Research Focus and Areas of Interest

1. Targeted Fat Tissue Reduction

Researchers are investigating Adipotide’s ability to bind endothelial cells in white adipose tissue and induce apoptosis. This targeted mechanism allows study of fat mass reduction via vascular disruption, without direct effects on muscle or organ tissues.

2. Metabolic Regulation Pathways

By altering adipose tissue mass, Adipotide may influence glucose handling and insulin response. Research has shown interest in how vascular targeting peptides might intersect with pathways linked to type 2 diabetes and systemic metabolism.

3. Vascular Targeting in Oncology

Because prohibitin and related proteins can also appear in tumour blood vessels, Adipotide is being studied as a model for selective angiogenic disruption. This opens a potential pathway for research into cancer vascular biology.

4. Tissue Remodeling and Signaling

Laboratory studies often explore Adipotide (FTPP) for its role in tissue remodeling, focusing on signaling pathways that regulate cellular communication and local microenvironments.

Conclusion

Adipotide (FTPP) represents a unique approach to studying fat tissue biology and targeted vascular disruption. Its design allows exploration of obesity, metabolic health, and oncology pathways in controlled laboratory settings. Supplied strictly for research use only, it is not intended for human or veterinary use.

 

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Technical Information:

• Synonyms: Adipotide; FTPP; Prohibitin-TP01

•Modified Single-Letter Sequence: CKGGRAKDC-GG-D(KLAKLAK)₂

• IUPAC Condensed Amino Acid Sequence: Cys-Lys-Gly-Gly-Arg-Ala-Lys-Asp-Cys-Gly-Gly-D-Lys-Leu-Ala-Lys-Leu-Ala-Lys-Leu-Ala-Lys

• Molecular Weight: 2611.4g/mol

• CAS Number: 859216-15-2

• PubChem CID: 163360068

• Further references: PubChem Link

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Stability, Source, and Handling

Stability: Stable for up to 36 months when stored at –20 °C or below, away from light and moisture.

Source: Produced via solid-phase peptide synthesis; supplied with Certificate of Analysis (COA) confirming purity and identity.

Reconstitution: Reconstitute with Bacteriostatic Water. After reconstitution, aliquot and store at –80 °C to prevent degradation.

Usage: Product is prepared for LABORATORY RESEARCH ONLY. Adipotide for sale at Pure Peptides UK is limited to scientific research and education only – Only buy Adipotide if you are a licenced researcher.