Premium Mod-GRF 5 mg (Modified GRF (1-29) / CJC-1295 without DAC)
Overview
Modified GRF (1-29), also known as CJC-1295 without DAC, is a synthetic peptide in the growth hormone-releasing hormone (GHRH) family. It is widely studied in biochemical and physiological research for its ability to stimulate the natural release of growth hormone (GH) from the pituitary gland.
This Premium 5 mg version offers the same high-purity formulation as the standard 2 mg product but in a larger quantity for extended research use.
Mod-GRF (1-29) lacks the Drug Affinity Complex (DAC) component found in other CJC-1295 analogues, resulting in a shorter half-life while retaining full biological potency. This makes it especially suitable for investigating pulsatile GH secretion and natural endocrine signalling patterns.
Scientific Background
Growth hormone plays a central role in cell growth, metabolism, repair, and regeneration. Mod-GRF (1-29) represents the biologically active fragment of endogenous GHRH — the first 29 amino acids responsible for receptor binding and activity.
By mimicking this natural sequence, Mod-GRF (1-29) triggers GH release from the pituitary in a rhythmic, physiological manner, closely resembling the body’s own pattern.
This makes it a key model for exploring hormonal regulation, growth factor pathways, and metabolic adaptation in research settings.
Mechanism of Action
Mod-GRF (1-29) binds to GHRH receptors in the anterior pituitary gland, activating intracellular signalling cascades that increase cyclic AMP (cAMP) levels and calcium ion concentrations — resulting in GH secretion.
Key characteristics include:
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Shorter half-life than DAC-modified versions, promoting natural pulse frequency.
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Endogenous regulation rather than artificial GH elevation.
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Synergistic potential when studied alongside GHRP-class peptides.
This precise mimicry of physiological GH pulsation makes Mod-GRF (1-29) a versatile tool in studies involving growth hormone dynamics and metabolic feedback mechanisms.
Research Focus Areas
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Endocrine Regulation – Investigating GH secretion and hypothalamic–pituitary interactions.
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Metabolic Modelling – Assessing GH’s role in lipid oxidation, glucose regulation, and energy metabolism.
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Muscle and Tissue Regeneration – Exploring GH-driven protein synthesis and recovery pathways.
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Age-Related Hormonal Decline – Studying how GH pulsatility changes with age and impacts cell maintenance.
Technical Details
- Synonyms: Mod-GRF (1-29), Modified GRF (1-29), CJC-1295 without DAC
- Sequence: YADAIFTNSYRKVLGQLSARKLLQDIMSR
- IUPAC Condensed: H-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NHâ‚‚
- Molecular Weight: 3367.95 g/mol
- CAS Number: 863288-34-0
- PubChem CID: 91976842
- Further References: PubChem
Stability and Storage
Store lyophilised protein at –20 °C.
After reconstitution, aliquot the solution to avoid repeated freeze–thaw cycles.
Reconstituted peptide may be kept at 4 °C for short-term use.
The lyophilised peptide remains stable until the expiry date when stored appropriately at –20 °C.
Source and Reconstitution
Source: Biosynthesis
Reconstitution: Reconstitute with Bacteriostatic Water
Usage
Product is prepared for LABORATORY RESEARCH ONLY.
Premium Mod-GRF 5 mg for sale at Pure Peptides UK is limited to scientific and educational use.
Only purchase Mod-GRF (1-29) if you are a licenced researcher.
Images for illustration purposes only.
Conclusion
Premium Mod-GRF 5 mg provides a higher-quantity format of this well-established GHRH analogue, ideal for researchers studying endogenous growth hormone release, metabolic regulation, and cellular recovery mechanisms.
Its natural pulsatile activity and short-acting profile make it a cornerstone peptide for endocrine and metabolic research.
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